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2018

Journal of Investigative Dermatology 2018 September

Age-dependent transformation of skin biomechanical properties and micromorphology during infancy and childhood

Authors : Joachim W. Fluhr1 , Gaëlle Bellemère2 , Chiara Ferrari3 , Clarence De Belilovsky4 , Gaëtan Boyer2 , Nadège Lachmann2 , Colin P. McGuckin5 , Nico Forraz5 , Razvigor Darlenski6 , Bernard Chadoutaud7, Philippe Msika2 , Caroline Baudouin2 , Giovanni Pellacani3

1 - Department of Dermatology, Charité Universitätsmedizin, Berlin, Germany ;
2 - Innovation R&D Direction, Laboratoires Expanscience, Epernon, France ;
3 - Department of Dermatology, University of Modena and Reggio Emilia, Italy
4 - Department of Dermatology, Institut Alfred Fournier, Paris, France ;
5 - CTIBIOTECH, Lyon, France
6 - Department of Dermatology and Venereology, Trakia University-Stara Zagora, Bulgaria ;
7 - Clinreal, Toulouse, France

Journal Of Medical Science and Clinical Research , March 2018

A Novel Topical Spray which Efficiently Provides Relief for Patients Suffering from Pruritus

Authors : Sandrine Virassamynaik1, Benoît Cadars1, Bernard Chadoutaud2, Michèle Sayag1
1Naos, Laboratoire Bioderma, Lyon, France
2Clin Real Online, Toulouse, France

Abstract

Background : Pruritus is defined as an “unpleasant sensation that elicits the desire or reflex to scratch”. It can occur without injury or disease, serves no apparent biological purpose and has no recognizable endpoint. It appears along with a number of skin and systemic diseases.

Aim : to determine the benefit of a novel topical anti-pruritic spray containing Camellia sinensis and Tambourissa spp leaf polyphenol extracts, and enoxolone in patients with atopic dermatitis (AD), psoriasis, chronic idiopathic urticaria (CIU) or senile pruritus.

Methodology : multicenter, prospective, observational, non-comparative study in 120 patients, 30 in each disease group. AD patients were to be aged between4monthsand 4years, psoriasis and CIU patients were to be of at least 18 years and senile pruritus patients of at least 65 years. At baseline and day 21, investigators assessed pruritus evolution using the 5-D pruritus scale, clinical efficacy and quality of life (QOL) through the Skindex-29 questionnaire in adults, the Infants’ Dermatitis OOL Index and Family Dermatitis Index in children. Local tolerance was assessed.

Results : The spray quickly and significantly provided relief from pruritus. The QOL of patients and the impact on their families significantly improved. A large majority of the patients appreciated the spray for its efficacy and its cosmetic properties. One adverse effect was reported in the AD group after 14 days of application, leading to the patient’s discontinuation. Local tolerance was good.

Conclusion : The spray product significantly decreased pruritus severity, allowing an improvement in the daily life of patients with pruritic diseases. Keywords : Pruritus, atopic dermatitis, psoriasis, chronic idiopathic urticaria, senile pruritus, itching, relief, spray.





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