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Journal of Dermatological Treatment 2010

Natural peroxisome proliferator-activated receptor-alpha agonist cream demonstrates similar therapeutic response to topical steroids in atopic dermatitis

Clarence De Belilovsky 1, Elia Roo-Rodriguez 2, Caroline Baudouin 3, Franck Menu 3, Bernard Chadoutaud 4 & Philippe Msika 3

1 Department of Dermatology, Institut Alfred Fournier, Paris, France
2 Department of Dermatology, Hospital Sur, Alcorcon, Madrid, Spain
3 Laboratoires Expanscience, Innovation Research and Development Direction, Epernon, France
4 ClinReal Online, Toulouse, France

Background :
Atopic dermatitis (AD) requires permanent skin care.

Objective :
A cream containing 2% SO (sunflower oleodistillate), with peroxisome proliferator-activated receptor-alpha (PPAR-α) agonist properties, has been compared to a topical steroid (hydrocortisone butyro-propionate 1 mg/g).

Methods :
An open, randomized study included two groups of 40 children (aged 3 months to 4 years).
Group A applied the steroid and group B applied the 2% SO cream, twice a day.
SCORAD (SCORing Atopic Dermatitis) was determined at D0, D7 and D21 and quality of life (QoL) at D0 and D21.

Results :
SCORAD was similar at D0 (37.2 versus 36.9), D7 (18.9 versus 19.2) (–49% and –48%) and D21 (11 versus 9.4) (–70% and –75%) (p < 0.01 versus D0).
The Infant Dermatitis Quality of Life and Dermatitis Family Impact Questionnaire improved similarly by 65%/67% in group A and 72%/75% in group B at D21 (p < 0.01 versus D0).

Conclusion :
A 2% SO cream has demonstrated therapeutic properties, using clinical scores and QoL, comparable to those of a topical steroid.

Abstract of the 10th Congress of the European Society of Contact Dermatitis (ESCD), Strasbourg, France, 15-18 September 2010

Evaluation of a non occlusive polymers ointment in a series of 71 cases of irritant contact dermatitis in building workers

A. Matta 1, M. Cleenewerck 1, P. Frimat 1, V. Chapalain 1, A. Gougerot 1 , B. Chadoutaud 2

1 Laboratoires Dermatologiques d’Uriage, Paris, France
2 ClinReal Online, Toulouse, France

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